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公司介绍
ImmunoStar是初级多克隆和单克隆抗体的原始制造商.。已经验证了七千引文ImmunoStar抗体的生物医学文献.我們的客戶包括美国和世界各地的各大高校, 医院, 企业, 政府和其他机构的神经科学家.。我們的免疫组织化学产品用于多种生物标记物的检测,包括帕金森氏病, 阿尔茨海默氏症 异常, 癫痫和癫痫发作的精神分裂症, 盧伽雷氏病, 和亨廷頓氏病。
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ImmunoStar/Neuropeptide Y Antibody/22940/1 Ea

ImmunoStar/Neuropeptide Y Antibody/22940/1 Ea
  • ImmunoStar/Neuropeptide Y Antibody/22940/1 Ea
商品介绍

Description

NeuropeptideY(NPY)isamemberofaregulatorypeptidefamilyandhasamarkedsequencehomologywithpancreaticpolypeptide(PP)andpeptideYY(PYY),whichareothermembersofthefamily. NPYiswidelyexpressedinthenervoussystemandhasbeenshowntobedifferentiallyexpressedininhibitoryinterneuronsinthehippocampusindegenerativedisease,asapowerfulvasoconstrictorintheperiphery,andincreasedexpressionofNPYinthehypothalamuscorrelateswithfoodintake.

Intheratcentralnervoussystem,immunohistochemistryhasfoundNPY-likecellbodiesinthecortex,caudate-putamen,hypothalamus(arcuatenucleus),hippocampus,anteriorwestolfactorybulb,nucleusaccumbens,amygdaloidcomplexandperiaqueductalgrey.NPY-likefibersandterminalsaredetectedinhighnumbersinthebednucleusofthestriaterminalis,theperi-andparaventricularregionsofthehypothalamusandthalamusandindiscretehypothalamicnuclei,particularlythesuprachiasmaticnucleus.

WesternsarenotrecommendedfortheNeuropeptideYantibodysincetheproteinistoosmalltodetectingel.

PhotoDescription: IHCimageofneuronsstainingforneuropeptideYintheratcortex(above)andstriatum(below).Thetissuewasfixedwith4%formaldehydeinphosphatebuffer,beforebeingremovedandpreparedforvibratomesectioning.FloatingsectionswereincubatedatRTin10%goatseruminPBS,beforestandardIHCprocedure.Primaryantibodywasincubatedat1:5000for48hours,goatanti-rabbitsecondarywassubsequentlyaddedfor1hourafterwashingwithPBS.Lightmicroscopystainingwasachievedwithstandardbiotin-streptavidin/HRPprocedureandDABchromogen.

Thesecondimageaboveentitled"C."isNPYinterneurons(RED)inmousestriatum,GREENstainingisGFPexpressedbymediumspinyneuronsprovidedAlipiNaydenov,NeuroBIOLOGyandBehavior,StellaLabUniversityofWashington(seereviewbelow).

NPY striatum

Host: Rabbit

Quantity/Volume: 100µL

State:LyophilizedWholeSerum

ReactsWith:Alpaca(Llama),Bird,BubalusBubalis(WaterBuffalo),Bullfrog,Cat,Ewe,Ferret,Fish,Frog,Frog(XenopusLaevis),GroundSquirrel,GuineaPig,Hamster,Human, Monkey,Mouse,Ovine(Sheep),Pig,PsettaMaxima(FlatFish),Rat,Sheep,Snake,Tadpole,Toad,Turtle,Zebrafish

AvailABIlity:InStock

PreabsorptionControl:AvailableatSigmaAldrich,Catalog#N3266

AlternateNames: Pro-neuropeptideY;Neuropeptidetyrosine;prepro-neuropeptideY;PYY4,anti-NPY

GeneSymbol/ID,Accession#: NPY,4852

RRID: AB_572253

品牌介绍

ImmunoStar是初级多克隆和单克隆抗体的原始制造商.。

已经验证了七千引文ImmunoStar抗体的生物医学文献.

我們的客戶包括美国和世界各地的各大高校, 医院, 企业, 政府和其他机构的神经科学家.。我們的免疫组织化学产品用于多种生物标记物的检测,包括帕金森氏病, 阿尔茨海默氏症 异常, 癫痫和癫痫发作的精神分裂症, 盧伽雷氏病, 和亨廷頓氏病。


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